.After increasing $170 million back in February, metabolic disease-focused BioAge Labs has actually filed to debut on everyone market.The Eli Lilly-partnered biotech wish to note on the Nasdaq under the sign “BIOA,” according to papers submitted with the Securities as well as Swap Compensation. The business has actually certainly not publicly discussed an anticipated financial amount for the offering.The clinical-stage company boasts lead prospect azelaprag, an orally provided tiny molecule slated to enter phase 2 testing in combination along with semaglutide– marketed by Novo Nordisk under brand name Wegovy for effective weight loss– in the 1st one-half of following year. Semaglutide is actually likewise sold as Ozempic and Rybelsus through Novo for diabetes.
Apelin receptor agonist azelaprag is created to combine effectively along with GLP-1 drugs, increasing weight-loss while protecting muscular tissue mass. The investigational medicine was located to become well-tolerated among 265 people across eight stage 1 tests, depending on to BioAge.Formerly, BioAge achieved the assistance of Lilly to manage a trial blending azelaprag along with the Significant Pharma’s GLP-1/ GIP receptor agonist tirzepatide, which is industried for diabetes as Mounjaro as well as Zepbound for fat burning. The partners are actually presently carrying out a phase 2 trial of azelaprag and tirzepatide, along with topline results anticipated in the third one-fourth of 2025.The biotech is actually additionally planning a the hormone insulin sensitivity proof-of-concept test examining azelaprag as a monotherapy in the 1st half of upcoming year to sustain prospective indicator expansion.
Furthermore, the business intends to inquire the FDA for authorization in the second fifty percent of 2025 to launch human testing for an NLRP3 prevention targeting metabolic conditions and also neuroinflammation.BioAge’s anticipated move to the general public market adheres to a light uptick in planned biotech IPOs coming from Bicara Rehabs as well as Zenas Biopharma. Zooming out, the current IPO garden is a “combined photo,” along with top quality companies still debuting on the public markets, just in minimized varieties, depending on to PitchBook.